The RNA binding protein FUS exerts its function in several RNA biosynthetic processes; moreover, mutations leading to changes in its expression levels or alterations in cellular compartmentalization have been linked to the pathogenesis of Amyotrophic Lateral Sclerosis.  Here, we describe an additional novel function of FUS, that is the control of back-splicing reactions which lead to circular RNA (circRNA) production. We identified circRNAs expressed in murine ES-derived motoneurons and then compared their levels in control versus FUS-/- cells. We discovered that a considerable number of circRNAs is affected by FUS levels. SOURCE: Stefano Dini Modigliani (stefano.dinimodigliani@uniroma1.it) -  Istituto Italiano di Tecnologia

Pluto Bioinformatics

GSE83226: The FUS protein participates in circRNA biogenesis