Pluto Bioinformatics

GSE89660: Comparison of gene expression patterns of two SCLC genetically-engineered mouse models; Rb1 floxed, Trp53 foxed, LSL-Myc T58A-IRES-Luc vs. Rb1 floxed, Trp53 foxed, RPR2 (p130) floxed

Bulk RNA sequencing

Myc expression cooperates with Rb1 and Trp53 loss in mouse lungs to generate rapid, aggressive, highly metastatic and neuroendocrine-low tumors which are similar to human variant subset of SCLC with high NEUROD1 expression. Targeted drug screening reveals that mouse and human MYC-driven SCLC are vulnerable to Aurora kinase inhibition in combination with chemotherapy in vivo. SOURCE: Trudy Oliver (Trudy.Oliver@hci.utah.edu) - Oliver University of Utah