Pluto Bioinformatics

GSE152961: The RNA-binding proteins Roquin-1 and Regnase-1 interact and cooperate to prevent autoimmunity

Bulk RNA sequencing

This study aimed to analyze the transcriptomic changes occuring after knockout of alleles encoding forthe RNA-binding proteins Roquin-1 and Roquin-2 (DKO), Regnase-1 (KO) or a combination of all three (TKO) in Th1 cells without orafter restimulation with anti-CD3/28 antibodies.; Data analysis revealed that in unstimulated as well as restimulated T cells of all three knockout genotypes a number of genes is differentially expressed compared to WT cells, with the strongest deregulation seen in TKO cells. A comparison of gene expression changes of all three genotypes indicated that cooperativity of Roquin and Regnase-1 is the prevalent mode of target regulation. SOURCE: Vigo HeissmeyerHeissmeyer lab Ludwig-Maximilians-Universit├Ąt

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