Here, we have studied the first stage of this infectionthe interaction of Mucor circinelloides spores with phagocytic cellsfrom an integrated transcriptomic and functional perspective. Our transcriptomic results showed that a relevant gene network is remodelled in response to phagocytosis, enriched in crucial functions to survive the phagosome, such as nutritional adaptation and response to oxidative stress. An additional transcriptomic analysis of atf1 and atf2 mutants unveiled the complex gene network of secondarily regulated genes involved in the response to phagocytosis. These new insights into the initial phase of mucormycosis define genetic regulators and molecular processes that could serve as pharmacological targets. SOURCE: Carlos Pérez-Arques (carlos.perez6@um.es) - Genómica y Biotecnología Molecular de Hongos Universidad de Murcia

Pluto Bioinformatics

GSE117385: Host-pathogen transcriptomics of Mucor circinelloides spores phagocytosed by mouse macrophages