Pluto Bioinformatics
GSE143743: Knocking out C9ORF72 exacerbates axonal trafficking defects associated with hexanucleotide repeat expansion and reduces levels of heat shock proteins I
Bulk RNA sequencing
iPSCs with mutant C9ORF72 were edited using CRISPR/Cas9 (1) to knockout C9ORF72 or, alternatively, (2) to correct the ALS mutation, followed by differentiation into motor neurons. SOURCE: Jared Sterneckert (Jared.Sterneckert@tu-dresden.de) - iPS Cells and Neurodegenerative Disease TU Dresden