Pluto Bioinformatics

GSE97541: A Unique B-cell Regulome links Notch to Downstream Oncogenic Pathways in Small B-cell Lymphoma

Bulk RNA sequencing

We perform integrative analysis of Notch-dependent transcripts, genome-wide binding of Notch transcription complex subunits, and enhancer-promoter interactions to identify direct Notch target genes, including the oncogene MYC, and validate their relevance to mantle cell lymphoma and chronic lymphocytic leukemia in vivo. SOURCE: Russell,James Hubbard,RyanSimches Research Center, Rm 8400 Massachusetts General Hospital

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