Pluto Bioinformatics

GSE83139: Single cell RNA-seq of human pancreatic endocrine cells from Juvenile, adult control and type 2 diabetic donors.

Bulk RNA sequencing

We successfully sequenced and annotated more than 400 cells from child, adult control, type 1 diabetes and type 2 diabetes donors. We detect donor-type specific transcript variation. We also report that cells from child donors have less defined gene signature. Cells from type 2 diabetes donors resemble juvenile cells in gene expression. SOURCE: Jonathan Schug (jschug@upenn.edu) - IDOM University of Pennsylvania