Pluto Bioinformatics

GSE148467: Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner

Bulk RNA sequencing

We report that monocytic (mMDSC) and granulocytic (gMDSC) MDSC susbsets have distinct expression profiles with ~300-1200 genes uniquely expressed on each subset. We further used these genes for pathway annotation. Our findings identified that mMDSC and gMDSC have unique pathway associations that can be targeted via distinct drug candidates. SOURCE: Tae Hyun Hwang (hwangt@ccf.org) - Hwang Lab Cleveland Clinic