Pluto Bioinformatics

GSE83132: Genes that mediate leptomeningeal metastasis from breast and lung solid tumor primaries

Bulk RNA sequencing

Little is understood about the gene expression changes that underlie cancer spread to the cerebrospinal fluid, or leptomeningeal metastasis. Using four cancer cell line models, we empolyed iterative in vivo selection to generate subpopulations of these cell lines able to access the leptomeningeal space and grow once there. We compared the gene expression profile of the terminally selected cells or "Lep" cells with that of the parental or "Par" cells, as well as that of an intermediate stage of in vivo selection or "Int" cells. Analyses for brain parenchymal metastatic derivatives or "BrM" cells were included for comparison. SOURCE: Yilong Zou (zouy@mskcc.org) - Memorial Sloan Kettering Cancer Center