Pluto Bioinformatics

GSE89482: Gene Expression in Cx3cr1-GFP+ Cells in PS2APP Alzheimer's Disease mice

Bulk RNA sequencing

This project defines the microglial gene expression profile in a transgenic mouse model of Alzheimer's, compared to non-transgenic age-matched controls, at a time when amyloid pathology and microgliosis are rampant. Microglia were sorted live from one hemisphere of cerebral cortex, using GFP expressed from Cx3cr1 locus (mice have one intact copy of Cx3cr1). RNA was isolated from sorted microglia using RNeasy mini. Two groups, PS2APP and non-transgenic, with 9 mice/group, aged 14-15 months.; The "SAMPLE_ID" sample characteristic is a sample identifier internal to Genentech.; The ID of this project in Genentech's ExpressionPlot database is PRJ0006715 SOURCE: Brad,A,Friedman (friedmab@gene.com) - Genentech, Inc.