Pluto Bioinformatics

Histone Deacetylase 3 is required for efficient T cell development (GSE72917)

Bulk RNA sequencing

Hdac3 is an important target of HDAC inhibitors used in the treatment of cutaneous T cell lymphoma. In order to gain an understanding of Hdac3 function in T cells,we deleted Hdac3 from early mouse thymocytes using LCK-Cre. Hdac3 deletion resulted in a loss of single positive thymocytes due to a defect in positive selection at the double positive (DP) stage of thymocyte development. To better characterize this defect, we sorted the DP1 and DP2 populations to for gene expression profiling. SOURCE: Scott Hiebert (scott.hiebert@vanderbilt.edu) - Dr, Scott Hiebert Vanderbilt University