Pluto Bioinformatics

GSE86417: RNA-seq of mouse embryonic stem cell states expressing Esrrb, Tbx3, and Zscan4

Bulk RNA sequencing

We develop a theoretical-computational framework for inferring cell state transition dynamics, and apply it to mouse embryonic stem cells states defined by expression levels of Esrrb, Tbx3, and Zscan4. RNA-seq was performed to characterize the larger transcriptional differences between states expressing combinations of these three specific genes, and proceed to explore their dynamic interconversion. SOURCE: Michael Elowitz (melowitz@caltech.edu) - Elowitz Lab Caltech