Pluto Bioinformatics

GSE154614: Gene expression and polysome profiling data of E-Myc B-lymphoma cells

Bulk RNA sequencing

Acute response to combinatorial ribosome-targeting therapy in vivo is associated with downregulation of the cells' translational activity and energy metabolism. Translational alterations drive therapeutic resistance by promoting elevated metabolic activity and activation of a cAMP-dependent pro-survival mechanism via EPAC1/2. SOURCE: Anna Trigos Peter MacCallum Cancer Centre