Pluto Bioinformatics

GSE69276: Notch1 dose modulates endothelial gene expression

Bulk RNA sequencing

Purpose: To use RNA-Seq analysis of endothelial cell in various Notch1 alllels in order to determine transcrptional differencesas a consequence of Notch dose.; Methods: Using a FACS sorting we generated high-throughput RNA-SEQ data of endothelials in various Notch1 alleles during development; Results: Notch1 dose can alter gene expression in a subset of endothelial genes SOURCE: Raphael Kopan Cincinnati Children's Hospital