Pluto Bioinformatics

GSE63183: Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer

Bulk RNA sequencing

Aberrant DNA methylation is common in cancer.; To associate DNA methylation with gene function, we performed RNAseq upon tumor tissue and matched normal tissues of two ccRCC (clear cell renal cell carcinoma) patients.; To quantify 5mC and 5hmC level in each CG site at genome-wide level, we performed BS-seq and TAB-seq upon tumor tissue and matched normal tissues of two ccRCC (clear cell renal cell carcinoma) patients, respectively. SOURCE: Jing Zhang (zhangj@big.ac.cn) - Beijing Institute of Genomics, Chinese Academy of Sciences