Pluto Bioinformatics

GSE113465: Evaluation of HSP90 inhibitor expsosure on Immune Cell Gene Expression

Bulk RNA sequencing

We report RNA-sequencing analysis of human peripheral blood mononuclear cells exposed to clinically recommended doses (500 nM) of the HSP90 inhibitor ganetispib. Global analysis of the expression profiles of treated cells revealed wide spread changes in gene expression, specifically, upregulation of protein folding and assembly pathways, with downregulation of antigen presentation through MHC Class I and Class I. SOURCE: Alex,M,Jaeger (ajaeger@mit.edu) - Jacks Massachusetts Institute of Technology