Pluto Bioinformatics

GSE117106: Gene expression changes in THP1 cells at day 2 and 4 following shRNA knock-down of RUVBL2

Bulk RNA sequencing

We used an inducible shRNA system and RNA-Seq to examine gene expression changes in acute myeloid leukemia THP1 cells following silencing of RUVBL2. RUVBL2 is a AAA+ ATPase that functions in a number of cellular processes, including chromatin remodeling and transcriptional control, and is critical for survival of acute myeloid leukemia cells and in vivo disease progression. SOURCE: Owen Williams (owen.williams@ucl.ac.uk) - UCL GOSICH