Pluto Bioinformatics

GSE63091: Transcriptome-wide modulation of splicing by the exon junction complex

Bulk RNA sequencing

We report that knockdown of EJC core proteins, eIF4A3, Y14, Magoh, causes a transcript-wide changes in alternative splicing, as well as some transcriptional changes. These changes are specific to EJC core proteins, and KD of UPF1 protein caused different sets of alterantive splicing changes. These changes are linked to the rate of transcription. SOURCE: Herve LE HIR (lehir@ens.fr) - Le Hir lab IBENS