Pluto Bioinformatics

GSE143304: Genome wide anaylsis of transcriptome modifications in male mice exposed to tributyltin during development

Bulk RNA sequencing

Purpose: To identify alterations induced by developmental exposure to tributyltin at different stages of life; Methods: Dams were treated with tributyltin during gestation and lactation in drinking water and pups were euthanized at different ages; Results: We identified a number of changes in transcriptomic activity in 5 month, and ten month old pups after tributyltin exposure. Male animals exposed to tributyltin also developed fatty liver 5 months of age and adenomas of the liver at ten months of age. SOURCE: Cheryl,L,Walker (cheryl.walker@bcm.edu) - Baylor College of Medicine