How genomic information is selectively utilized to direct spatial and temporal gene expression patterns during differentiation remains to be elucidated but it is clear that regulated changes in higher-order genomic architecture plays a fundamental role. Specifically, long range interactions within and between chromosomes and the position of chromosome territories in the nucleus are controlled by TADs and LADs respectively, but the relationship between these genomic organizers remains poorly understood SOURCE: Philippe Collas University of Oslo

Pluto Bioinformatics

GSE109924: TAD cliques shape the 4-dimensional genome during dual lineage terminal differentiation