Pluto Bioinformatics

GSE143282: Profiling astrocyte spatial heterogeneity and region-specific transcription factor networks

Bulk RNA sequencing

The goals of this study are to profile the molecular signatures of astrocytes from four brain regions (olfactory bulb, hippocampus, cortex, and brainstem) and determine if differential transcription factor enrichment may play a role in shaping astrocyte spatial diversity. We performed RNA-seq on astrocytes from the olfactory bulb, hippocampus, cortex, and brainstem, and determined region-specific molecular signatures. Using transcription factor motif discovery analysis on each region-specific gene signature we uncovered universal and region-specific transcription factor expression profiles. SOURCE: Brittney Lozzi (lozzi@bcm.edu) - Benjamin Deneen Baylor College of Medicine