Pluto Bioinformatics

GSE102792: Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy

Bulk RNA sequencing

Cardiac-restricted deletion of myocardin-related transcription factors (MRTFs) in adult mice leads to partially penetrant lethality and rapid deterioration in cardiac physiology in response to trans-aortic constriction (TAC). The goals of the RNA-seq are to define the gene programs altered in MRTF-depleted cardiomyocytes compared to control cardiomyocytes 7 days after TAC surgery. SOURCE: Eric Small (eric_small@urmc.rochester.edu) - University of Rochester