Pluto Bioinformatics

GSE131264: Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen

Bulk RNA sequencing

To characterize the changes that had occurred in splenic pre-cDCs in the absence of ADAM10, we performed RNA sequencing on sorted pre-cDC1 and 2 from the spleens of wild-type and ADAM10DC mice. Unsupervised hierarchical clustering and principal component analysis of all four groups demonstrated that distinct transcriptomic changes had taken place in ADAM10DC pre-cDC2, while minimal changes were observed for pre-cDC1 SOURCE: Kaibo Duan (duan_kaibo@immunol.a-star.edu.sg) - Singapore Immunology Network