Pluto Bioinformatics

GSE72759: Defining the consequences of genetic variation on a proteome-wide scale

Bulk RNA sequencing

Genetic variation governs protein expression through both transcriptional and post-transcriptional processes. To investigate this relationship, we combined a multiplexed, mass spectrometry-based method for protein quantification with an emerging mouse model harboring extensive genetic variation from 8 founder strains. We collected genome-wide mRNA and protein profiling measurements to link genetic variation to protein expression differences in livers from 192 Diversity Outcross mice. SOURCE: Steven,C,Munger (steven.munger@jax.org) - Steven Munger The Jackson Laboratory