Pluto Bioinformatics

GSE145774: Multi-omics HUVEC data of Tibetan and Han in hypoxic induction.

Bulk RNA sequencing

Tibetan's adaptation to high-altitude environment at the Qinghai-Tibetan plateau represents a remarkable case of natural selection during recent human evolution. We generated time series paired RNAseq, ATACseq and Hi-C data in Tibetan and Han Chinese's umbilical endothelial cells from normoxia to hypoxia condition. Our results provide a broad resource of genome-wide hypoxia regulatory network to characterize the effect of genetic variation in high-altitude adaptation, and indicates large-scale maps of variants need proper cell types to understand its act on gene regulation. SOURCE: Jingxue Xin (jxxin@amss.ac.cn) - Chinese Academy of Sciences