Pluto Bioinformatics

GSE99824: Molecular pathogenesis of human prostate basal cell hyperplasia reveals a keratinocyte metaplasia

Bulk RNA sequencing

The incidence of basal cell hyperplasia (BCH) has been reported at 8-10%, but a molecular and cellular characterization has not been performed on this phenotype. Using freshly digested tissue from surgical specimens, we performed transcriptomic analysis of flow cytometry-purified basal epithelia from patients with and without a majority BCH phenotype. Gene set enrichment analysis revealed an increased expression of members of the epidermal differentiation complex, resembling the progression of other metaplastic diseases. SOURCE: Gervaise,H.,Henry (gervaise.henry@utsouthwestern.edu) - Strand Lab UT Southwestern Medical Center