Pluto Bioinformatics

GSE92560: Loss of JNK in Breast Epithelium Accelerates Tumor Formation

Bulk RNA sequencing

Members of the JNK pathway have been found to be mutated in human breast cancer. Mouse studies examining JNK loss in different tissues have demonstrated that the JNK pathway can play a role in cancer. Using and autochthonous mouse model, we found that JNK deficiency on a p53-null background resulted in more rapid tumor onset. To learn more about these tumors we generated cells lines and performed various in vitro assays, as well as RNAseq in hope of finding differentially expressed genes that may explain the differences we observed in vivo. SOURCE: Yvonne EdwardsPMM Bioinformatics Core University of Massachusetts