Pluto Bioinformatics

GSE97184: Intestinal epithelial and intraepithelial T cell crosstalk mediates a dynamic response to infection

Bulk RNA sequencing

Oral infection of mice with Salmonella Typhimurium leads to rapid changes in small intestinal TCRgd IEL behavior. How these changes are induced is currently unknown. By analyzing the transcriptome of TCRgd and intestinal epithelial cells in the steady state and after infection, we find a potential role for epithelial cell MYD88 expression in regulating the IEL response. By additionally analyzing the transcriptome of epithelial cell-specific, conditional Myd88 knockout animals after Salmonella infection, we address the role of epithelial cell Myd88 signaling in regulating the IEL and EC response to Salmonella infection. SOURCE: Daniel Mucida (mucida@rockefeller.edu) - Laboratory of Mucosal Immunology The Rockefeller University