Pluto Bioinformatics

GSE157281: Holistic characterization of single hepatocyte transcriptome responses to high fat diet

Bulk RNA sequencing

Purpose: The goals of this study are to investigate the effects of the long-term high-fat diet to transcriptome of mouse hepatocytes utilizing single cell RNA-seq (scRNA-seq) technology.; Methods: Hepatocytes were obtained from three mice that had been fed with the high-fat diet (HFD) and two mice that had been treated with the regular diet (LFD). After isolation and enrichment, hepatocytes were subjected to Drop-seq. SOURCE: Jun Hee Lee ( - University of Michigan

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