Pluto Bioinformatics

GSE72487: A transcription factor pulse can prime chromatin for heritable transcriptional memory [RNAseq]

Bulk RNA sequencing

To indentify genes displaying long-term transcriptionnal memory (LTTM) we used a trans-differentiation system where Bcell are reprogramed into macrophages upon induction of the transcription factor Cebpa. We performed RNAseq in untreated Bcells, after 12h of Cebpa induction and after 6days of wash of Cebpa, to see if any genes respond more/faster in a second stimulation than in the first. SOURCE: samuel Collombet (samuel.collombet@ens.com) - Thieffry Ecole Normale Superieure