Pluto Bioinformatics

GSE58286: Transcriptome comparison of pancreatic islets of Urocortin3 null islets and wild type controls.

Bulk RNA sequencing

The peptide hormone Urocortin3 (Ucn3) is abundantly expressed by mature beta cells, yet its physiological role is unknown. Transcriptome data from Ucn3 null islets compared to wild type controls reveals selective depletion for delta cell markers and supports a role for Ucn3 as a trigger for somatostatin-mediated negative feedback. SOURCE: Mark,O.,Huising (mhuising@ucdavis.edu) - Huising lab University of California, Davis