Pluto Bioinformatics

GSE103528: CARM1/PRMT4 is essential for myeloid leukemogenesis but dispensable for normal hematopoiesis

Bulk RNA sequencing

We investigated the role of PRMT4 in normal and malignant hematopoiesis.; We found that knockdown of PRMT4 impairs cell cycle progression, induces apoptosis, and downgretulateds E2F target genes in leukemia cell lines, identifying several mechanisms for the leukemia-specific dependence on PRMT4. SOURCE: Stephen Nimer University of Miami