Pluto Bioinformatics

GSE127459: The Wnt pathway inhibitor, LGK974 has suppressive effects for LPS-induced endotoxemia

Bulk RNA sequencing

We demonstrated that Wnt/-catenin pathway was activated in in endotoxemic mice, and the modulation of this pathway by LGK974 had beneficial effects by suppressing the inflammation and lethality caused by endotoxemia. SOURCE: Minwoo Park (mwpark@e-biogen.com) - ebiogen