We found that approximately 200 genes were differentially expressed between CD11b+ lung-migratory dendritic cells (CD11b+ mDCs) from adult and infant mice treated with house dust mite allergen + LPS, and that the TNFa-via NFkB signaling pathway was significantly enriched in CD11b+ mDCs from adults relative to those from infants. Specifically, out of the 200 genes in the hallmark TNFa-via NFkB signaling pathway that were analyzed, 31 genes were significantly downregulated in CD11b+ mDCs from infants compared to CD11b+ mDCs from adults. SOURCE: Beatriz Leon Ruiz (bleon@uab.edu) - Shelby 406 University of Alabama at Birmingham

Pluto Bioinformatics

GSE110046: Impaired TNFa-driven dendritic cell activation limits LPS-induced protection from asthma in infants.