Pluto Bioinformatics

GSE125816: RNA sequencing of lung innate lymphoid cell (ILC) populations

Bulk RNA sequencing

A transitory, interleukin-25-responsive, KLRG1high Group 2 innate lymphoid (ILC2) cell subset that migrates to mucosal tissues early during type-2 inflammation was recently identified. This study focuses on understanding the significance of this population in relation to tissue-resident ILC2 cells in the lung and intestine. RNA-sequencing and unbiased pathway analysis revealed the AP-1 factor BATF as a potential modulator of ILC2 cell fate. For RNAseq, KLRG1-postive and KLRG1-neagive populations were sorted and compared. SOURCE: Richard,Lee,Reinhardt ( - Reinhardt National Jewish Health

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