Pluto Bioinformatics

GSE116982: Cancer associated mutants of eIF1A impair Rps3/Rps10 binding and enhance scanning of cell cycle genes [Mars-seq]

Bulk RNA sequencing

The Ribo-seq analysis demonstrated that eIF1A is predominantly essential for translation of genes with long 5'UTR genes including cell proliferation and cell cycle progression genes. eIF1A depletion causes broad stimulation of initiation in 5UTRs at near-cognate AUG codons that diminshes the translation initiation fidelity SOURCE: Dena Leshkowitz (dena.leshkowitz@weizmann.ac.il) - Weizmann Institute of Science