Pluto Bioinformatics

GSE50760: Gene expression profiling study by RNA-seq in colorectal cancer

Bulk RNA sequencing

The objective of this study is to identify a prognostic signature in colorectal cancer (CRC) patients with diverse progression and heterogeneity of CRCs. We generated RNA-seq data of 54 samples (normal colon, primary CRC, and liver metastasis) from 18 CRC patients and, from the RNA-seq data, identified significant genes associated with aggressiveness of CRC. Through diverse statistical methods including generalized linear model likelihood ratio test, two significantly activated regulators were identified. In the validation cohorts, two activated regulators were independent risk factors and potential chemotherapy-sensitive agenets in colorectal cancers. SOURCE: Seon-Kyu Kim Korea Research Institutue of Bioscience & Biotechnology