Pluto Bioinformatics

GSE116130: A human TH17 population with a tissue-resident signature in healthy and inflamed oral mucosal tissues [10x]

Bulk RNA sequencing

T cells in mucosal tissues fulfill a complex array of duties to ensure maintenance of barrier immunity. In oral mucosa tissue, we found that increased inflammation altered CD4 T cell subsets in a spatially-dependent manner, although it had a modest effect on the frequency of tissue-resident memory T cells (TRM) and the CD4 T cell transcriptome. In contrast, localization to the tissue profoundly altered the transcriptional profile, emphasizing the importance of studying healthy tissue to understand disease-specific changes. Our data revealed the existence of a TH17 cell population that is predominantly found in the tissue-resident, but not transient, CD4 T cell compartment in mucosal tissue. SOURCE: Scott Presnell (spresnell@benaroyaresearch.org) - Benaroya Research Institute