Pluto Bioinformatics

GSE115769: RNA-Sequencing of carnosine treated wild-type BDF1 (WT) and transgenic Thy1-aSyn mice

Bulk RNA sequencing

Mitochondrial dysfunction plays a central role in the pathogenesis of neurodegenerative diseases such as Parkinsons disease (PD). This study tested the hypothesis that the dipeptide carnosine would exert a beneficial effect in the Thy1-aSyn mouse model of PD, whichdisplays mitochondrialdysfunction. Mitochondrial function and gene expressionwere evaluatedin the midbrain after two months of carnosine administration by intranasal (IN) or drinking water routes of exposure.IN carnosine attenuated transcriptional changes in the midbrain in Thy1-aSyn mice. Additionally, IN-carnosine increased expression of mitochondria complexes and enhanced mitochondrial function, suggesting a potential neuroprotective role for IN-carnosine in PD. SOURCE: Mei-Ling Bermudez (bermudmn@mail.uc.edu) - University of Cincinnati