Pluto Bioinformatics

GSE112732: Genome-wide transcriptional analysis of human patterned induced neurons (hpiNs)

Bulk RNA sequencing

We report that combining NGN2 programming with SMAD and WNT inhibition generates patterned induced neurons (hpiNs).Transcriptional analyses showed that hpiN cultures contained cells along a developmental continuumranging from poorly differentiated neuronal progenitors to well-differentiated, excitatory glutamatergic neurons. The most differentiated neurons could be identified using a CAMK2A::GFP reporter gene. SOURCE: Ralda Nehme (rnehme@broadinstitute.org) - Broad Institute

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