The transcriptomes of differentiated and undifferentiated E14 (male), Pgk12.1 (female; WT) and Pgk12.1 with a KO of Rlim (RlimKO) were elucidated and examined for differences in X chromosome inactivation. No significant differences between wt and RlimKO with respect to Xist expression and global X-silencing was detected. Results confirm that Rlim is not required for XCI in female ESCs. SOURCE: Ingolf Bach (ingolf.bach@umassmed.edu) -  University of Massachusetts Medical School

Pluto Bioinformatics

GSE101838: Rlim-independent XCI in female embryonic stem cells in vitro