Pluto Bioinformatics

GSE123680: Hsa-miR-139-5p/HNRNPF axis modulates gene-transcripts balance in thyroid cancer cells

Bulk RNA sequencing

We explored alternative splicing events upon hsa-miR-139-5p/HNRNPF axis regulation in our cell system using the Multivariate Analysis of Transcript Splicing (rMATS) computational tool (https://doi.org/10.1073/pnas.1419161111). Differential analysis of major splicing outcomes (skipped exon, alternative 5/3 splice, mutually exclusive exons and retained intron) revealed a total of 174 events significantly activated or repressed (FDR<0.05) upon HNRNPF regulation. SOURCE: Osvaldo GrañaBioinformatics Unit CNIO