Pluto Bioinformatics

GSE96938: Gene expression of mouse brain and mouse microglia in NRROS WT and NRROS KO animals

Bulk RNA sequencing

Mice deficient in NRROS exhibit neurological phenotype similar to ALS. Our previous work showed that in phagocytes, NRROS regulates the degradation of Nox2, the enzymatic component of the NADPH oxidase that generates reactive oxygen species. NRROS is expressed in phagocytes, including macrophages, neutrophils and microglia but not neurons.; ; Keywords: Expression profiling by high throughput sequencing SOURCE: Mark McCreary (mccrearm@gene.com) - Genentech