Pluto Bioinformatics

GSE131025: 3D genome architecture orchestrates activity-dependent gene expression in neurons

Bulk RNA sequencing

Post-mitotic neurons in the mammalian brain form synapses that dynamically remodel throughout an individuals lifetime to encode learning and memory. Here, we create high-resolution genome folding maps in >12 Megabases around IEGs and synaptic genes and find that 12% of long-range looping interactions are induced de novo during cortical neuron activation. SOURCE: Jennifer,E,Phillips-Cremins (jcremins@seas.upenn.edu) - University of Pennsylvania