Pluto Bioinformatics

GSE145210: Transcriptome network analysis of Smug1 knock-out cells by using CRISPR/Cas9 system

Bulk RNA sequencing

Purpose: To build a differential transcriptome network in Smug1 knock-out HepG2 hepatocarcinoma cells.; Methods: Transcriptome analysis by the RNA-seq via mRNA pull-down.; Results: We constructed transcriptome from Smug1 knock-out cells by using RNA-seq analysis. Nucleosome and miRNA related genes were highly enriched in Smug1 KO HepG2 cells.; Conclusions: Smug1 regulate the gene expression related with nucleosome assembly and histone function. SOURCE: Jung-Woong Kim (jwkim0508@gmail.com) - Genome Dynamics Lab Chung-Ang University