Pluto Bioinformatics

GSE109991: Slfn2 Regulates Type I Interferon Responses by Modulating the NFB Pathway

Bulk RNA sequencing

We demonstrate that Slfn2 interacts with protein phosphatase 6 regulatory subunit 1 (PPP6R1), leading to reduced type I IFN-induced activation of nuclear factor kappa B (NFB) signaling, resulting in reduced expression of ISGs. SOURCE: Mariafausta Fischietti ( - Northwestern University

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