RNA-seq technology was used to reveal the transcriptome changes of tubular epithelia in response to fluid flow and determine the role of primary cilia in this process. Many fluid flow-sensitive genes were identified, among which are those regulated by primary cilia sensing of fluid flow. These genes were further validated by RT-qPCR. SOURCE: Joost Hoenderop (Joost.Hoenderop@radboudumc.nl) - Ion transport Radboud Institute for Molecular Life Sciences

Pluto Bioinformatics

GSE109701: Primary cilia sensing-regulated transcriptome in the collecting duct