We previously identified TLR-independent expression of 4933430F08Rik, encoding Batf2, in T. cruzi-infected bone marrow-derived dendritic cells (BMDCs) (Kayama et al., 2009). To determine the functions of Batf2 in innate immune responses, we performed a comprehensive gene expression analysis in wild-type and Batf2-/- bone marrow-derived macrophages (BMM). RNA-seq analysis showed that 98 genes are upregulated in Batf2-/- BMM stimulated with LPS following IFN- treatment, when compared with that in wild-type cells. Among these genes, we focused on Il23a, encoding IL-23p19, because IL-23 is able to promote expression of Il17a in Th17 cells. SOURCE: Daisuke Okuzaki (dokuzaki@biken.osaka-u.ac.jp) -  RIMD, Osaka univ.

Pluto Bioinformatics

GSE81724: A comprehensive analysis of gene expression patterns in wild-type and Batf2-/- bone marrow-derived macrophages (BMM)