Pluto Bioinformatics

GSE76879: Expression profiling of p53-/- shPU.1 AML cells single cell clones

Bulk RNA sequencing

We have utilized advanced RNAi technology to dynamically restore endogenous PU.1 expression in p53-deficient shPU.1 AML single cell clones in vitro. This causes rapid cell cycle shutdown and reversible myeloid differentiation. SOURCE: Ruijie Liu (cliu@wehi.edu.au) - Ritchie lab walter and eliza hall institute of medical research