Pluto Bioinformatics

GSE157121: Transcriptional response of thyroid to iodide in wild-type and Nrf2 knockout mice

Bulk RNA sequencing

Analysis of differentially expressed mRNAs indicated that iodide overload upregulated inflammatory-, immune-, fibrosis- and oxidative stress-related pathways, including the Nrf2 pathway. Nrf2 KO mice showed a more pronounced inflammatory-autoimmune transcriptional response to iodide SOURCE: Dionysios Chartoumpekis ( - Endocrinology University of Patras

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